Good News for Coffee Devotees: Top 12 Clinical Findings on the Health Impact of Coffee Drinking

Researchers from the University of Toronto have shown that simply viewing coffee-related reminders is enough to promote attentiveness and mental alertness. Additionally, according to the results of a Stevens Institute of Technology study, the smell of coffee alone may boost analytical performance for examinees taking the Graduate Management Aptitude Test (GMAT), which is usually a requirement in business schools. But your go-to caffeine-in-a-cup habit does more than just increase your mental alertness and energy. Take a look at these clinical findings that demonstrate coffee’s positive health benefits.

Bowel Movement

Caffeine content has nothing to do with coffee’s ability to ease bowel movement, so decaf fans can still enjoy this particular health benefit. What coffee actually does to the bowels is alter the composition of the gut biome, therefore increasing muscle motility and improving intestinal contraction, according to the presentation made by researchers from the University of Texas Medical Branch during the May 2019 Digestive Disease Week.

Prostate Cancer

According to a study whose findings have been presented at the 2019 European Association of Urology congress in Barcelona, Spain, the specific coffee compounds that can stop the growth of prostate cancer cells have now been identified. Their pilot testing involved a cell culture with drug-resistant prostate cancer cells. Two hydrocarbons in coffee, kahweol acetate, and cafestol, have been recognized for their ability to impede prostate cancer growth. This important discovery could lead to the development of new prostate cancer drugs.

Chronic Liver Disease

Daily coffee and tea drinking may help prevent the development of the unhealthy lifestyle-related disorder that is also the world’s twelfth cause of death. A paper published in the Journal of Hepatology suggests that a few cups a day of coffee and tea may safeguard the liver against fibrosis or scarring, the degree of which is measured in terms of liver stiffness. But of course, when it comes to chronic liver disease, there is nothing more important than effectively preventing it by maintaining an active and healthy lifestyle.

Parkinson’s and Alzheimer’s Disease

Two independent studies have shown coffee’s potential in helping prevent decline from Parkinson’s and Alzheimer’s disease. Research from the Krembil Brain Institute identified phenylindanes, a group of compounds present in both decaf and caffeinated coffees, to possess the unique ability to inhibit the clumping of amyloid and tau proteins associated with Parkinson’s and Alzheimer’s disease. In a separate study, researchers from Rutgers University showed that brain degeneration in Parkinson’s disease may be fought off with caffeine in combination with a chemical found in the waxy coat of coffee beans.

Type 2 Diabetes

In an Aarhus University-funded study, it has been found that lowering the risk for type 2 diabetes may be as easy and inexpensive as the daily consumption of three to four cups of coffee. New preventives for type 2 diabetes can be someday developed based on this finding.

Cardiovascular Health

The caffeine equivalent of drinking four cups of coffee has a protective impact on cardiovascular health, according to a team of researchers from institutions such as Heinrich-Heine-University and the IUF-Leibniz Research Institute for Environmental Medicine. It has been established that caffeine prevents damage to heart cells through its ability to promote the migration of a specific regulatory protein called p27 into the cell’s mitochondria.

Longer Life

With the exception of pregnant women and those with elevated risks for fractures, the daily consumption of three to four cups of coffee may safely and generally lead to a longer lifespan, suggests a study conducted by researchers from the University of Southampton and the University of Edinburgh. Understandably, no specific causal link has been established between regular coffee drinking and longer lifespan.

All in all, the associated health impact of regular coffee drinking outweighs the risks for adult consumers, according to a paper published in the journal of the Institute of Food Technologists.

Researchers have listed, among coffees numerous health benefits, improvement of metabolism, and gastrointestinal state. Just keep in mind to limit your coffee intake because researchers from the University of South Australia have shown that the risk for developing heart disease rises by up to 22 percent with daily consumption of six or more cups of coffee.


  • Eugene Y. Chan, Sam J. Maglio. Coffee cues elevate arousal and reduce level of construal. Consciousness and Cognition, 2019; 70: 57.

  • Adriana Madzharov, Ning Ye, Maureen Morrin, Lauren Block. The impact of coffee-like scent on expectations and performance. Journal of Environmental Psychology, 2018.

  • Hiroaki Iwamoto, Kouji Izumi, Ariunbold Natsagdorj, Renato Naito, Tomoyuki Makino, Suguru Kadomoto, Kaoru Hiratsuka, Kazuyoshi Shigehara, Yoshifumi Kadono, Kazutaka Narimoto, Yohei Saito, Kyoko Nakagawa‐Goto, Atsushi Mizokami. Coffee diterpenes kahweol acetate and cafestol synergistically inhibit the proliferation and migration of prostate cancer cells. The Prostate, 2018.

  • Louise J.M. Alferink, Juliana Fittipaldi, Jessica C. Kiefte-de Jong, Pavel Taimr, Bettina E. Hansen, Herold J. Metselaar, Josje D. Schoufour, M. Arfan Ikram, Harry L.A. Janssen, Oscar H. Franco, Sarwa Darwish Murad. Coffee and herbal tea consumption is associated with lower liver stiffness in the general population: The Rotterdam study. Journal of Hepatology, 2017.

  • Ross S. Mancini, Yanfei Wang, Donald F. Weaver. Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation. Frontiers in Neuroscience, 2018.

  • Run Yan, Jie Zhang, Hye-Jin Park, Eun S. Park, Stephanie Oh, Haiyan Zheng, Eunsung Junn, Michael Voronkov, Jeffry B. Stock, M. Maral Mouradian. Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB. Proceedings of the NationalAcademy of Sciences, 2018.

  • Fredrik Brustad Mellbye, Per Bendix Jeppesen, Kjeld Hermansen, Søren Gregersen. Cafestol, a Bioactive Substance in Coffee, Stimulates Insulin Secretion and Increases Glucose Uptake in Muscle Cells: Studies in Vitro. Journal of Natural Products, 2015.

  • Niloofar Ale-Agha, Christine Goy, Philipp Jakobs, Ioakim Spyridopoulos, Stefanie Gonnissen, Nadine Dyballa-Rukes, Karin Aufenvenne, Florian von Ameln, Mark Zurek, Tim Spannbrucker, Olaf Eckermann, Sascha Jakob, Simone Gorressen, Marcel Abrams, Maria Grandoch, Jens W. Fischer, Karl Köhrer, René Deenen, Klaus Unfried, Joachim Altschmied, Judith Haendeler. CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system–New mode of action for caffeine. PLOS Biology, 2018.

  • Robin Poole, Oliver J Kennedy, Paul Roderick, Jonathan A Fallowfield, Peter C Hayes, Julie Parkes. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ, 2017.

  • L. Kirsty Pourshahidi, Luciano Navarini, Marino Petracco, J.J. Strain. A Comprehensive Overview of the Risks and Benefits of Coffee Consumption. Comprehensive Reviews in Food Science and Food Safety, 2016.

  • Ang Zhou, Elina Hyppönen. Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases. The American Journal of Clinical Nutrition, 2019.